How to use
neffy

Use neffy as soon as you notice symptoms of an allergic reaction.

All devices shown are not actual size.
All patients shown are actor portrayals.

How to use neffy

Step 1 - Remove1

Remove

Remove neffy from packaging.
Pull open the packaging to remove the neffy nasal spray device.

Step 2 - Hold2

Hold

Hold device as shown. Hold the device with your thumb on the bottom of the plunger and a finger on either side of the nozzle.

  • Do not pull or push on the plunger.
  • Do not test or prime (pre-spray). Each device has only 1 spray.
Step 3 - Insert3

Insert

Insert the nozzle into a nostril until your fingers touch your nose.
Keep the nozzle straight
into the nose pointed toward your forehead.

  • Do not point (angle) the nozzle to the nasal septum (wall between your 2 nostrils) or outer wall of the nose.
Step 4 - press4

Press

Press plunger up firmly until it snaps up and sprays liquid into the nostril.

  • Do not sniff during or after the dose is given. If any liquid drips out of the nose, you may need to give a second dose of neffy after checking for symptoms.

When using neffy

  • Each neffy nasal spray device has only 1 dose of medicine and is for single-use only.
  • Always carry 2 neffy nasal spray devices with you.
  • Patient can be in any position
    (eg, sitting, standing, lying, reclining).

After using neffy

Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed, after using neffy. Tell them that a neffy nasal spray has been used.

Check for symptoms after the first dose of neffy. If symptoms get worse or come back, give a second dose of neffy in the SAME nostril starting 5 minutes after the first dose.

Watch these videos to learn how to use neffy

Child (4 years & older; 33 lbs to <66 lbs)

Get a neffy
demonstration device

Practice using the demonstration device so you are prepared to use neffy on yourself or your child in time of need. These devices are air filled and do not contain epinephrine.

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WHAT IS neffy?

neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children aged 4 years and older who weigh 33 lbs or greater.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about neffy?

neffy contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes.

Always carry two neffy nasal sprays with you because you may not know when anaphylaxis may happen and because you may need a second dose of neffy if symptoms continue or come back. Each neffy contains a single dose of epinephrine. neffy is for use in the nose only.

Use neffy right away, as soon as you notice symptoms of an allergic reaction. If symptoms continue or get worse after the first dose of neffy, a second dose is needed. If needed, administer a second dose using a new neffy in the same nostril starting 5 minutes after the first dose. Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed after using neffy.

Tell your healthcare provider if you have underlying structural or anatomical nasal conditions, about all the medicines you take, and about all your medical conditions, especially if you have heart problems, kidney problems, low potassium in your blood, Parkinson's disease, thyroid problems, high blood pressure, diabetes, are pregnant or plan to become pregnant, or plan to breastfeed.

Tell your healthcare provider if you take or use other nasal sprays or water pills (diuretics) or if you take medicines to treat depression, abnormal heart beats, Parkinson's disease, heart disease, thyroid disease, medicines used in labor, and medicines to treat allergies. neffy and other medications may affect each other, causing side effects. neffy may affect the way other medicines work, and other medicines may affect how neffy works.

What are the side effects of neffy?

neffy may cause serious side effects. If you have certain medical conditions or take certain medicines, your condition may get worse, or you may have more or longer lasting side effects when you use neffy.

Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.

Tell your healthcare provider if you have any side effects that bother you or that do not go away after using neffy.

These are not all of the possible side effects of neffy. Call your healthcare provider for medical advice about side effects. To report side effects, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the full Prescribing Information and Patient Information for neffy.

ARS Pharmaceuticals Operations, Inc. website

© 2025 ARS Pharmaceuticals Operations, Inc. All rights reserved. “ARS Pharma,” the ARS Pharma logo design, “neffy,” the neffy logo, and the neffyconnect logo are trademarks or registered trademarks of ARS Pharmaceuticals Operations, Inc. All other trademarks are the property of their respective owners. NEF-US-0046-13 | 06/2025